发明公开
EP2827896A1 STABLE PEPTIDE MIMETICS OF THE HIV-1 GP41 PRE-HAIRPIN INTERMEDIATE
审中-公开
STABLE肽模拟物的HIV-1 GP41 PRE-发夹中间体
- 专利标题： STABLE PEPTIDE MIMETICS OF THE HIV-1 GP41 PRE-HAIRPIN INTERMEDIATE
- 专利标题（中）： STABLE肽模拟物的HIV-1 GP41 PRE-发夹中间体
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申请号： EP13763727.8申请日： 2013-03-15
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公开(公告)号： EP2827896A1公开(公告)日： 2015-01-28
- 发明人: JOYCE, Joseph G. , WU, Chengwei , OTTINGER, Elizabeth A. , GARSKY, Victor
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Böhles, Elena
- 优先权： US201261613264P 20120320
- 国际公布： WO2013142298 20130926
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C12N7/00 ; G01N33/53 ; A61K38/00
摘要：
The present invention relates to a gp41 trivalent peptide mimetic having three gp41 N-peptides on a chemical scaffold which conformationally constrains the N-peptides into a trimeric coiled-coil to mimic gp41 presentation. The present invention also relates to N-peptides having the entire HIV gp41 NH2-terminal heptad repeat region and which are capable of forming gp41 peptide mimetics. Such peptide mimetics of HIV-1 gp41 pre-hairpin intermediates can be utilized in a vaccine for the treatment or prevention of HIV-1 infection through eliciting neutralizing antibodies.
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