Provided are methods and apparatuses for device-to-device (D2D) communication. The method includes: configuring dedicated subframe(s) according to cellular uplink hybrid automatic repeat request (HARQ) process(es), the dedicated subframe(s) being used for D2D communication (S302); generating indication signaling according to the configuration of the dedicated subframe(s), wherein the indication signaling is used for indicating the dedicated subframe(s) (S304); and transmitting the indication signaling to user equipment (S306). The technical solutions can ensure the reliability of data transmission and the compatibility of cellular transmission and D2D communication that are performed simultaneously, and improve the user experience.