发明公开
EP2834220A1 4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS
有权
4-羟基 - 异喹啉酮双羟肟酸羟脯氨酸抑制剂
- 专利标题： 4 -HYDROXY- ISOQUINOLINE COMPOUNDS AS HIF HYDROXYLASE INHIBITORS
- 专利标题（中）： 4-羟基 - 异喹啉酮双羟肟酸羟脯氨酸抑制剂
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申请号： EP13712970.6申请日： 2013-03-08
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公开(公告)号： EP2834220A1公开(公告)日： 2015-02-11
- 发明人: HO, Wen-Bin , ZHAO, Hongda , DENG, Shaojiang , NG, Danny , WRIGHT, Lee R. , WU, Min , ZHOU, Xiaoti , AREND, Michael P. , FLIPPIN, Lee A.
- 申请人： Fibrogen, Inc.
- 申请人地址： 409 Illinois Street San Francisco, CA 94158 US
- 专利权人： Fibrogen, Inc.
- 当前专利权人： Fibrogen, Inc.
- 当前专利权人地址： 409 Illinois Street San Francisco, CA 94158 US
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US201261609022P 20120309
- 国际公布： WO2013134660 20130912
- 主分类号： C07D217/26
- IPC分类号： C07D217/26 ; C07D401/12 ; C07D407/12 ; C07D409/12 ; A61K31/4725 ; A61P21/00 ; A61P9/10 ; A61P1/00
摘要：
The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.
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