发明公开
EP2841423A1 METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF
有权
PROCESS FOR 5-（二氟甲基）吡嗪-2-羧酸和中间体及其制备
- 专利标题： METHOD FOR PRODUCING 5-(DIFLUOROMETHYL)PYRAZINE-2-CARBOXILIC ACID AND PRODUCTION INTERMEDIATE THEREOF
- 专利标题（中）： PROCESS FOR 5-（二氟甲基）吡嗪-2-羧酸和中间体及其制备
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申请号： EP13781634.4申请日： 2013-04-25
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公开(公告)号： EP2841423A1公开(公告)日： 2015-03-04
- 发明人: YOSHIZAWA, Kazuhiro , OMORI, Masayuki , WATANABE, Yuzo , NAGAI, Mitsuo , TAKAHASHI, Masabumi , FANG, Francis, G.
- 申请人： Eisai R&D Management Co., Ltd.
- 申请人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112-8088 JP
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： 6-10, Koishikawa 4-chome Bunkyo-ku Tokyo 112-8088 JP
- 代理机构： Hoffmann Eitle
- 优先权： US201261639362P 20120427
- 国际公布： WO2013162065 20131031
- 主分类号： C07D241/24
- IPC分类号： C07D241/24 ; C07B61/00
摘要：
5-(Difluoromethyl)pyrazine-2-carboxilic acid, which is a raw material for the construction of 5-(difluoromethyl)pyrazine-2-carboxamide, which is a common partial structural motif of the compound having an A production inhibitory action or a BACE1 inhibitory action, can be industrially advantageously produced by decarboxylating 5-[carboxy(difluoro)methyl]pyrazine-2-carboxylic acid, which is obtainable from 5-chloropyrazine-2-carboxylate.
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