发明公开
- 专利标题: A DELAYED RELEASE DRUG FORMULATION
- 专利标题(中): 延迟释放药物制剂
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申请号: EP13719543.4申请日: 2013-04-29
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公开(公告)号: EP2844220A1公开(公告)日: 2015-03-11
- 发明人: BRAVO GONZÁLEZ, Roberto Carlos , BUSER, Thomas , GOUTTE, Frédéric Jean-Claude , BASIT, Abdul, Waseh. , VARUM, Felipe, José, Oliveria. , FREIRE, Ana,Cristina.
- 申请人: TILLOTTS PHARMA AG
- 申请人地址: Baslerstrasse 15 4310 Rheinfelden CH
- 专利权人: TILLOTTS PHARMA AG
- 当前专利权人: TILLOTTS PHARMA AG
- 当前专利权人地址: Baslerstrasse 15 4310 Rheinfelden CH
- 代理机构: Beck Greener
- 优先权: EP12166110 20120430; US201261640217P 20120430
- 国际公布: WO2013164315 20131107
- 主分类号: A61K9/00
- IPC分类号: A61K9/00 ; A61K9/28 ; A61K31/606 ; A61K47/32 ; A61K47/36
摘要:
Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and the coating comprises an inner layer and an outer layer. The outer layer comprises a mixture of a first polymeric material which is susceptible to attack by colonic bacteria, and a second polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a third polymeric material which is soluble in intestinal fluid.
公开/授权文献
- EP2844220B1 A DELAYED RELEASE DRUG FORMULATION 公开/授权日:2019-01-23
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