发明公开
EP2844302A2 VIRAL VECTORS FOR THE TREATMENT OF RETINAL DYSTROPHY
审中-公开
VIRALE VEKTOREN ZUR BEHANDLUNG VON RETINALER DYSTROPHIE
- 专利标题： VIRAL VECTORS FOR THE TREATMENT OF RETINAL DYSTROPHY
- 专利标题（中）： VIRALE VEKTOREN ZUR BEHANDLUNG VON RETINALER DYSTROPHIE
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申请号： EP13730648.6申请日： 2013-05-02
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公开(公告)号： EP2844302A2公开(公告)日： 2015-03-11
- 发明人: BIGELOW, Chad Eric , CHOI, Vivian , DRYJA, Thaddeus Peter , POLICE, Seshidhar Reddy
- 申请人： Novartis AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Dyer, James
- 优先权： US201261642630P 20120504; US201361776167P 20130311
- 国际公布： WO2013164793 20131107
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N15/864
摘要：
The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and Muller cells of the retina. The invention also relates nucleic acids useful for producing viral vectors, compositions comprising the viral vectors and uses of the compositions and viral vectors. The invention also relates to methods of delivering and/or expressing a heterologous gene to the retina, improving the rate of dark adaption in a subject and treating RLBP1-associated retinal dystrophy.
公开/授权文献
- EP2844302B1 VIRAL VECTORS FOR THE TREATMENT OF RETINAL DYSTROPHY 公开/授权日：2023-03-15
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