发明公开
EP2845864A3 Peptides and related molecules that bind to TALL - 1
审中-公开
Peptide und verwandteMoleküle，die zuGroß - 1 binden
- 专利标题： Peptides and related molecules that bind to TALL - 1
- 专利标题（中）： Peptide und verwandteMoleküle，die zuGroß - 1 binden
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申请号： EP14180109.2申请日： 2002-05-13
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公开(公告)号： EP2845864A3公开(公告)日： 2015-06-10
- 发明人: Min, Hosung , Hsu, Hailing , Xiong, Fei
- 申请人： Amgen, Inc
- 申请人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 专利权人： Amgen, Inc
- 当前专利权人： Amgen, Inc
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, CA 91320-1799 US
- 代理机构： Donald, Jenny Susan
- 优先权： US290196P 20010511
- 主分类号： C07K14/715
- IPC分类号： C07K14/715 ; C07K7/06 ; C07K7/08 ; C12N15/62 ; C12N15/63 ; C12N5/10 ; A61K38/08 ; A61K38/10
摘要：
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz 2 Lz 4 wherein the z 2 is an amino acid residue and z 4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae a 1 a 2 a 3 CDa 6 La 8 a 9 a 10 Ca 12 a 13 a 14 (SEQ.ID.NO:100), b 1 b 2 b 3 Cb 5 b 6 Db 8 Lb 10 b 11 b 12 b 13 b 14 Cb 16 b 17 b 18 (SEQ.ID.NO:104), c 1 c 2 c 3 Cc 5 Dc 7 Lc 9 c 10 c 11 c 12 c 13 c 14 Cc 16 c 17 c 18 (SEQ.ID.NO:105), d 1 d 2 d 3 Cd 5 d 6 d 7 WDd 10 Ld 13 d 14 d 15 Cd 16 d 17 d 18 (SEQ.ID.NO:106), e 1 e 2 e 3 Ce 5 e 6 e 7 De 9 Le 11 Ke 13 Ce 15 e 16 e 17 e 19 (SEQ.ID.NO:107), f 1 f 2 f 3 Kf 5 Df 5 Lf 9 f 10 Qf 12 f 13 f 14 (SEQ.ID.NO:109) wherein the substituents are defined in the specification. The invention further comprises compositions of matter of the formula (X 1 ) a -V 1 -(X 2 ) b wherein V 1 is a vehicle that is covalently attached to one or more of the above TALL-1 I modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
公开/授权文献
- EP2845864A2 Peptides and related molecules that bind to TALL - 1 公开/授权日：2015-03-11
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