发明授权
- 专利标题： PYRROLO[2,1-F][1,2,4]TRIAZINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF
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申请号： EP13798006.6申请日： 2013-04-23
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公开(公告)号： EP2857403B1公开(公告)日： 2018-10-10
- 发明人: YANG, Chunhao , MENG, Linghua , CHEN, Yanhong , WANG, Xiang , TAN, Cun , LI, Jiapeng , DING, Jian , CHEN, Yi
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai Haihe Pharmaceutical Co., Ltd.
- 申请人地址： 555 Zu Chong Zhi Road Zhangjiang Hi-Tech Park Pudong New District Shanghai 201203 CN
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Haihe Pharmaceutical Co., Ltd.
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai Haihe Pharmaceutical Co., Ltd.
- 当前专利权人地址： 555 Zu Chong Zhi Road Zhangjiang Hi-Tech Park Pudong New District Shanghai 201203 CN
- 代理机构： dompatent von Kreisler Selting Werner - Partnerschaft von Patent- und Rechtsanwälten mbB
- 优先权： CN201210177980 20120531
- 国际公布： WO2013177983 20131205
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D519/00 ; A61K31/5377 ; A61K31/5386 ; A61P35/00
摘要：
The present invention relates to a pyrrolo[2,1- f ][1,2,4]triazine compound, an isomer thereof or a pharmaceutically acceptable salt, ester or hydrate thereof, and a preparation method and application thereof. The pyrrolo[2,1- f ][1,2,4]triazine compound has a structure expressed in general formula (I). The pyrrolo[2,1- f ][1,2,4]triazine compound expressed in general formula (I) can inhibit a phosphatidylinositol-3 kinase (PI3K) signal pathway, thereby being used to prepare medicine for treating phosphatidylinositol-3 kinase related diseases such as cancer.
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