发明公开
- 专利标题： ANTIGEN-BINDING MOLECULE FOR ELIMINATING AGGREGATED ANTIGENS
- 专利标题（中）： 抗生素抗氧化剂抗生素抗氧化剂
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申请号： EP13796975.4申请日： 2013-05-30
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公开(公告)号： EP2857419A1公开(公告)日： 2015-04-08
- 发明人: IGAWA, Tomoyuki , HIRONIWA, Naoka , ITO, Eriko
- 申请人： Chugai Seiyaku Kabushiki Kaisha
- 申请人地址： 5-1, Ukima 5-chome Kita-ku Tokyo 115-8543 JP
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： 5-1, Ukima 5-chome Kita-ku Tokyo 115-8543 JP
- 代理机构： Vossius & Partner
- 优先权： JP2012123782 20120530
- 国际公布： WO2013180201 20131205
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; A61K39/395 ; A61P43/00 ; C07K16/42 ; C12P21/08 ; G01N33/15 ; G01N33/50 ; C12N15/09
摘要：
The present inventors discovered that incorporating an Fc region and an antigen-binding domain whose antigen-binding activity varies depending on ion concentration into an antigen-binding molecule that binds to an aggregate-forming antigen produces an antigen-binding molecule that can preferentially clear protein aggregates in comparison to protein monomers from plasma. Use of antigen-binding molecules of the present invention allows various diseases stemming from target tissues to be treated target-tissue-specifically. Use of antigen-binding molecules of the present invention enables treatment of diseases caused by protein aggregates.
公开/授权文献
- EP2857419B1 ANTIGEN-BINDING MOLECULE FOR ELIMINATING AGGREGATED ANTIGENS 公开/授权日：2021-01-13
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