- 专利标题： FUSION POLYPEPTIDES COMPRISING MUCIN-DOMAIN POLYPEPTIDE LINKERS
- 专利标题（中）： 融合蛋白多糖多肽
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申请号： EP13800676.2申请日： 2013-06-06
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公开(公告)号： EP2858672A2公开(公告)日： 2015-04-15
- 发明人: ALVAREZ, Juan , MCSWEENEY, Leslie, A.
- 申请人： Alkermes, Inc.
- 申请人地址： 852 Winter Street Waltham, MA 02451 US
- 专利权人： Alkermes, Inc.
- 当前专利权人： Alkermes, Inc.
- 当前专利权人地址： 852 Winter Street Waltham, MA 02451 US
- 代理机构： Chapman, Paul William
- 优先权： US201261657264P 20120608; US201261657285P 20120608; US201261657378P 20120608; US201261723081P 20121106; US201361778812P 20130313; US201361778575P 20130313
- 国际公布： WO2013184938 20131212
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The invention provides fusion proteins having improved bioactivity comprising a first polypeptide fusion partner and a second polypeptide fusion partner wherein the first fusion partner is linked to the second fusion partner by a mucin-domain polypeptide linker and wherein the bioactivity of the fusion protein of the invention is improved as compared to fusion of the first polypeptide fusion partner and the second polypeptide fusion partner in the absence of the mucin-domain polypeptide linker. Mucin-domain polypeptide linkers comprise a mucin domain that is rich in potential glycosylation sites, and has a high content of serine and/or threonine and proline, which can represent greater than 40% of the amino acids within the mucin domain and further comprise at least about 60% of its mass due to the glycans.
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