发明公开
- 专利标题： HUMAN BISPECIFIC EGFRvIII ANTIBODY ENGAGING MOLECULES
- 专利标题（中）： 人类双特异性抗体分子EGFRVII
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申请号： EP13800038.5申请日： 2013-06-07
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公开(公告)号： EP2861619A1公开(公告)日： 2015-04-22
- 发明人: BIGNER, Darell , KUAN, Chien-Tsun , SAMPSON, John , CHOI, Bryan , PASTAN, Ira H. , GEDEON, Patrick C.
- 申请人： Duke University , The Government of the United States of America, as represented by The Department of Health and Human Services
- 申请人地址： 2812 Erwin Road, Suite 306 P.O. Box 90083 Durham, North Carolina 27705 US
- 专利权人： Duke University,The Government of the United States of America, as represented by The Department of Health and Human Services
- 当前专利权人： Duke University,The Government of the United States of America, as represented by The Department of Health and Human Services
- 当前专利权人地址： 2812 Erwin Road, Suite 306 P.O. Box 90083 Durham, North Carolina 27705 US
- 代理机构： Tombling, Adrian George
- 优先权： US201261656717P 20120607
- 国际公布： WO2013185010 20131212
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; C12N15/13 ; A61K39/395 ; A61P35/00
摘要：
We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second arm that specifically engages T cell activation ligand CD3. The engaging moleculess are highly cytotoxic and antigen-specific. These are promising therapeutic agents.
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