Disclosed are a method for conducting data encryption and decryption using a symmetric cryptography algorithm and a table look-up device. The method comprises: when it is determined that it is required to use S-boxes to look up a table in a symmetric cryptography algorithm, determining all types of S-boxes to be used; for each type of S-box, determining the total number N i of the type of S-box, and when N i is larger than 1, determining that the type of S-box meets a multiplexing condition; and when data encryption and decryption are conducted using the symmetric cryptography algorithm, multiplexing at least one type of S-box which meets the multiplexing condition. The present application can reduce the occupation by the symmetric cryptography algorithm of hardware resources under the condition of comparative shortage of hardware resources.