The present invention relates to a frame (1) for fixation of equipment (10) to the head of a patient during neurological diagnosis, therapy or surgery. The frame (1) is adapted to enclose the head of the patient. The frame (1) comprises a number of mounting slots (2) arranged in said frame (1), said mounting slots (2) being adapted to receive a number of fixation pins adapted to fixate said frame (1) to a bone in said head. The frame (1) further comprising two anterior longitudinal posts (3) and two posterior longitudinal posts (4), extending along a longitudinal axis A, an anterior portion (5), adapted to be arranged at the anterior side of the head, said anterior portion (5) interconnecting said two anterior longitudinal posts (3), and a posterior portion (6), adapted to be arranged at the posterior side of the head, said posterior portion (6) interconnecting said two posterior longitudinal posts (4). The anterior longitudinal posts (3) and said posterior longitudinal posts (4) are interconnected with two lateral portions (7), adapted to extend one on each side of said head, and wherein said lateral portions (7) are axially offset, along said longitudinal axis A, with respect to said anterior and posterior portion (5, 6). The present invention further relates to a stereotactic frame system (10) comprising such frame (1).