发明公开
- 专利标题： INDOLECARBOXAMIDE DERIVATIVE
- 专利标题（中）： 吲哚酰胺衍生物
-
申请号： EP13816547.7申请日： 2013-07-09
-
公开(公告)号： EP2873660A1公开(公告)日： 2015-05-20
- 发明人: KANAYAMA, Takatoshi , KUBOTA, Hideki , MATSUMOTO, Shunichiro , SAITO, Tomoyuki , SHIMIZU, Takafumi , KATOH, Naoto , MATSUI, Shigeo
- 申请人： Astellas Pharma Inc.
- 申请人地址： 5-1, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 专利权人： Astellas Pharma Inc.
- 当前专利权人： Astellas Pharma Inc.
- 当前专利权人地址： 5-1, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103-8411 JP
- 代理机构： Hoffmann Eitle
- 优先权： JP2012154322 20120710
- 国际公布： WO2014010602 20140116
- 主分类号： C07D209/42
- IPC分类号： C07D209/42 ; A61K31/4045 ; A61K31/407 ; A61K31/437 ; A61P13/10 ; C07D471/04 ; C07D491/048
摘要：
[Problem]
To provided a compound which is useful as an MT1 and/or MT2 receptor agonist.
[Means for Solution]
The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the MT1 and/or MT2 receptor agonistic action as well as a low CNS penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like.
To provided a compound which is useful as an MT1 and/or MT2 receptor agonist.
[Means for Solution]
The present inventors have conducted studies on MT1 and/or MT2 receptor agonists, and have found that an indole carboxamide compound has an MT1 and/or MT2 receptor agonistic action, thereby completing the present invention. The indole carboxamide compound of the present invention has the MT1 and/or MT2 receptor agonistic action as well as a low CNS penetration, and therefore, it can be used as an agent for preventing and/or treating urological diseases; in one embodiment, lower urinary tract symptoms; in another embodiment, urine storage symptom, in another embodiment, urinary incontinence; in a still another embodiment, stress urinary incontinence; and the like.
公开/授权文献
- EP2873660B1 INDOLECARBOXAMIDE DERIVATIVE 公开/授权日：2016-10-26
信息查询
