A dynamic sense circuit to determine memristor states within a memristor crossbar array that includes a differential comparator made up of a resistance capacitance (RC) network to capture a reference voltage and a differential pre-amp to operate in an open loop mode to dynamically compare the reference voltage to a sense voltage. An alternating current (AC) coupled amplifier receives the output of the comparator and outputs an amplified signal. A set-reset (SR) latch samples and holds the amplified signal as a digital value.