- 专利标题： GLYCOSIDASE INHIBITORS AND USES THEREOF
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申请号： EP13834204申请日： 2013-08-29
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公开(公告)号： EP2890675A4公开(公告)日： 2016-01-13
- 发明人: MCEACHERN ERNEST J , SUN JIANYU , VOCADLO DAVID J , ZHOU YUANXI , ZHU YONGBAO , SELNICK HAROLD G
- 申请人： ALECTOS THERAPEUTICS INC , MERCK SHARP & DOHME
- 专利权人： ALECTOS THERAPEUTICS INC,MERCK SHARP & DOHME
- 当前专利权人： ALECTOS THERAPEUTICS INC,MERCK SHARP & DOHME
- 优先权： US201261695987 2012-08-31
- 主分类号： C07D207/12
- IPC分类号： C07D207/12 ; A61K31/40 ; A61K31/428 ; A61K31/4439 ; A61P25/28 ; C07D401/06 ; C07D417/06 ; C07H13/02 ; C12N9/24
摘要：
The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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