发明公开
EP2890708A2 PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF
有权
甲状旁腺激素，胰岛素，并与相关肽和方法进行生产及其用途KNOCHENANZIELENDEN相关单位
- 专利标题： PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF
- 专利标题（中）： 甲状旁腺激素，胰岛素，并与相关肽和方法进行生产及其用途KNOCHENANZIELENDEN相关单位
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申请号： EP13832369.6申请日： 2013-08-28
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公开(公告)号： EP2890708A2公开(公告)日： 2015-07-08
- 发明人: DOSCHAK, Michael , YANG, Yang , BHANDARI, Krishna, Hari
- 申请人： The Governors of the University of Alberta , Doschak, Michael , Yang, Yang , Bhandari, Krishna, Hari
- 申请人地址： 4000 Enterprise Square 10230 Jasper Avenue Edmonton, Alberta T5J 4P6 CA
- 专利权人： The Governors of the University of Alberta,Doschak, Michael,Yang, Yang,Bhandari, Krishna, Hari
- 当前专利权人： The Governors of the University of Alberta,Doschak, Michael,Yang, Yang,Bhandari, Krishna, Hari
- 当前专利权人地址： 4000 Enterprise Square 10230 Jasper Avenue Edmonton, Alberta T5J 4P6 CA
- 代理机构： Wilkins, Christopher George
- 优先权： US201261693818P 20120828
- 国际公布： WO2014033540 20140306
- 主分类号： C07K14/65
- IPC分类号： C07K14/65 ; A61K38/28 ; A61P19/08 ; C07K14/62 ; C07K14/635 ; C07K17/08
摘要：
Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate
de novo bone turnover and stimulate bone fracture repair.
de novo bone turnover and stimulate bone fracture repair.
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