发明授权
- 专利标题： A METHOD FOR SELECTION OF AGENTS INFLUENCING INTESTINAL MOTILITY DISORDERS AND PAIN
- 专利标题（中）： 选择影响肠道运动障碍和疼痛的药物的方法
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申请号： EP13756897.8申请日： 2013-09-03
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公开(公告)号： EP2893045B1公开(公告)日： 2018-05-16
- 发明人: CONNOLLY, Eamonn , KUNZE, Wolfgang , BIENENSTOCK, John
- 申请人： Biogaia AB
- 申请人地址： Kungsbroplan 3A P.O. Box 3242 103 64 Stockholm SE
- 专利权人： Biogaia AB
- 当前专利权人： Biogaia AB
- 当前专利权人地址： Kungsbroplan 3A P.O. Box 3242 103 64 Stockholm SE
- 代理机构： Owen, Deborah Jane
- 优先权： US201261696277P 20120903
- 国际公布： WO2014033330 20140306
- 主分类号： C12N1/20
- IPC分类号： C12N1/20 ; C12Q1/02
摘要：
A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.
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