An audio system such as a hearing assistance system includes an audio source device wirelessly communicating with one or more audio sink (destination) devices. The audio source and sink devices each include a sample clock for processing audio signal that is digitized and wirelessly transmitted. The sample clock of each of the one or more audio sink devices is synchronized to the sample clock of the audio source device to prevent audio sample over-runs or under-runs causing undesirable audio artifacts. In one embodiment, because audio packets may be lost in transmission, packet loss concealment techniques are used to improve audio reproduction. In one embodiment, link layer information is used for audio phase lock loop jitter reduction in the audio system.