An oral hygiene system for cleaning teeth and gums includes a mouthpiece having at least one arcuate channel adapted to receive and surround the teeth. The mouthpiece includes at least two modalities chosen from a group consisting of a mechanical modality, an iontophoretic modality, and a disinfection modality, wherein the mechanical modality brushes the teeth and gums and dislodges food debris, the iontophoretic modality breaks up plaque and tartar buildup, and the disinfection modality removes the food debris, plaque and tartar buildup. A control system coordinates the transmission of modalities, tracks and records utilization, recording completed and failed treatment cycles, and transmits them to a monitoring system. The monitoring system, which links to electronic medical administrating record (eMAR) technology and patient tracking technology (e.g., RFID sensors, electronic tags), facilitates compliance with recommended oral hygiene regimens and review of compliance by medical staff, assisted living staff, and/or caregivers.