发明公开
EP2900637A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1
有权
噻唑或咪唑取代的嘧啶，吡啶并吡嗪AMID衍生物和相关化合物ABL1，ABL2与BCR-ABL1-抑制剂用于癌症特异性病毒感染的治疗和具体CNS疾病
- 专利标题： COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1
- 专利标题（中）： 噻唑或咪唑取代的嘧啶，吡啶并吡嗪AMID衍生物和相关化合物ABL1，ABL2与BCR-ABL1-抑制剂用于癌症特异性病毒感染的治疗和具体CNS疾病
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申请号： EP13730654.4申请日： 2013-05-09
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公开(公告)号： EP2900637A1公开(公告)日： 2015-08-05
- 发明人: FURET, Pascal , GROTZFELD, Robert Martin , JONES, Darryl Brynley , MANLEY, Paul , MARZINZIK, Andreas , MOUSSAOUI, Saliha , PELLE, Xavier Francois Andre , SALEM, Bahaa , SCHOEPFER, Joseph , JAHNKE, Wolfgang
- 申请人： Novartis AG
- 申请人地址： Lichtstrasse 35 4056 Basel CH
- 专利权人： Novartis AG
- 当前专利权人： Novartis AG
- 当前专利权人地址： Lichtstrasse 35 4056 Basel CH
- 代理机构： Dyer, James
- 优先权： US201261647197P 20120515; US201361787513P 20130315
- 国际公布： WO2013171641 20131121
- 主分类号： C07D213/81
- IPC分类号： C07D213/81 ; C07D213/85 ; C07D317/60 ; C07D231/12 ; C07D233/38 ; C07D233/54 ; C07D401/04 ; C07D239/26 ; C07D239/30 ; C07D239/34 ; C07D407/14 ; C07D241/12 ; C07D241/20 ; C07D277/20 ; A61K31/505
摘要：
The present invention relates to compounds of formula I: in which Y, Y
1 , Y
4 , Y
5 , Y
6 , R
1 , R
2 , R
3 and R
4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
1 , Y
4 , Y
5 , Y
6 , R
1 , R
2 , R
3 and R
4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
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