发明公开
EP2904003A1 CELL PENETRATING PEPTIDES WHICH BIND IRF5
审中-公开
ZENENPENETRIERENDE PEPTIDE ZUR BINDUNG VON IRF5
- 专利标题: CELL PENETRATING PEPTIDES WHICH BIND IRF5
- 专利标题(中): ZENENPENETRIERENDE PEPTIDE ZUR BINDUNG VON IRF5
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申请号: EP13774129.4申请日: 2013-10-07
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公开(公告)号: EP2904003A1公开(公告)日: 2015-08-12
- 发明人: DEMARTINO, Julie , FOTOUHI, Nader , HOFFMAN, Ann , HUANG, Kuo-Sen , MILLETTI, Francesca , PANICKER, Sandip , SRINIVASAN, Dinesh , TAN, Seng-Lai
- 申请人: F.Hoffmann-La Roche AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F.Hoffmann-La Roche AG
- 当前专利权人: F.Hoffmann-La Roche AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Haefele Racin, Thomas
- 优先权: US201261710817P 20121008
- 国际公布: WO2014056813 20140417
- 主分类号: C07K14/47
- IPC分类号: C07K14/47
摘要:
The present invention comprises cell penetrating peptides that bind to interferon regulatory factor IRF5 and disrupt the IRF5 homo-dimerization and/or attenuate downstream signaling, and a method for screening peptides that inhibit IRF5. Generally, the cell penetrating peptides of the invention bind human interferon regulatory factor IRF5 (CPP-IRF5).
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