发明公开
EP2904016A1 FC-FREE ANTIBODIES COMPRISING TWO FAB-FRAGMENTS AND METHODS OF USE
审中-公开
FC-FREIEANTIKÖRPERMIT ZWEI FAB-FRAGMENTEN SOWIE VERWENDUNGSVERFAHRENDAFÜR
- 专利标题： FC-FREE ANTIBODIES COMPRISING TWO FAB-FRAGMENTS AND METHODS OF USE
- 专利标题（中）： FC-FREIEANTIKÖRPERMIT ZWEI FAB-FRAGMENTEN SOWIE VERWENDUNGSVERFAHRENDAFÜR
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申请号： EP13773229.3申请日： 2013-10-03
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公开(公告)号： EP2904016A1公开(公告)日： 2015-08-12
- 发明人: BRUENKER, Peter , FAUTI, Tanja , JAEGER, Christiane , KLEIN, Christian , UMAÑA, Pablo
- 申请人： Roche Glycart AG
- 申请人地址： Wagistrasse 18 8952 Schlieren CH
- 专利权人： Roche Glycart AG
- 当前专利权人： Roche Glycart AG
- 当前专利权人地址： Wagistrasse 18 8952 Schlieren CH
- 代理机构： Townsend, Carolin
- 优先权： EP12187647 20121008
- 国际公布： WO2014056783 20140417
- 主分类号： C07K16/46
- IPC分类号： C07K16/46 ; C07K16/28 ; C07K16/30
摘要：
The present invention relates to bispecific antibodies comprising at least two Fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged and the two Fab fragments are connected to each other by two peptide linkers; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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