发明公开
EP2906553A1 OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES
审中-公开
[ORTHO-BI（HETERO）ARYL] - [2-（META-BI（HETERO）ARYL） - 吡咯烷-1-基] - 乙二醇或邻苯二甲酰亚胺
- 专利标题： OREXIN RECEPTOR ANTAGONISTS WHICH ARE [ORTHO BI (HETERO )ARYL]-[2-(META BI (HETERO)ARYL)-PYRROLIDIN-1-YL]-METHANONE DERIVATIVES
- 专利标题（中）： [ORTHO-BI（HETERO）ARYL] - [2-（META-BI（HETERO）ARYL） - 吡咯烷-1-基] - 乙二醇或邻苯二甲酰亚胺
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申请号： EP13805561.1申请日： 2013-10-09
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公开(公告)号： EP2906553A1公开(公告)日： 2015-08-19
- 发明人: BOLLI, Martin , BOSS, Christoph , BROTSCHI, Christine , GUDE, Markus , HEIDMANN, Bibia , SIFFERLEN, Thierry , WILLIAMS, Jodi T.
- 申请人： Actelion Pharmaceuticals Ltd.
- 申请人地址： Gewerbestrasse 16 4123 Allschwil CH
- 专利权人： Actelion Pharmaceuticals Ltd.
- 当前专利权人： Actelion Pharmaceuticals Ltd.
- 当前专利权人地址： Gewerbestrasse 16 4123 Allschwil CH
- 代理机构： Velker, Jörg
- 优先权： EP12188019 20121010; EP13157809 20130305
- 国际公布： WO2014057435 20140417
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; C07D413/14 ; C07D403/04 ; C07D403/14 ; C07D413/04 ; C07D417/04 ; C07D417/14 ; C07D419/04 ; C07D419/14 ; A61K31/41 ; A61P25/00
摘要：
The present invention relates to [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives of formula (I) wherein R, and the rings A1 A2 and A3 are as described in the description, to pharmaceutically acceptable salts thereof, to their preparation, to pharmaceutical compositions containing one or more compounds of formula (I), and to their use as pharmaceuticals, especially to their use as orexin receptor antagonists.
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