发明公开
- 专利标题: ETHYNYL DERIVATIVES AS MODULATORS OF MGLUR5 RECEPTOR ACTIVITY
- 专利标题(中): 乙炔基衍生物作为MGLUR5受体活性的调节剂
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申请号: EP13776810.7申请日: 2013-10-15
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公开(公告)号: EP2909179A1公开(公告)日: 2015-08-26
- 发明人: JAESCHKE, Georg , LINDEMANN, Lothar , RICCI, Antonio , RUEHER, Daniel , STADLER, Heinz , VIEIRA, Eric
- 申请人: F.Hoffmann-La Roche AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F.Hoffmann-La Roche AG
- 当前专利权人: F.Hoffmann-La Roche AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Poppe, Regina
- 优先权: EP12189015 20121018
- 国际公布: WO2014060394 20140424
- 主分类号: C07D213/81
- IPC分类号: C07D213/81 ; A61K31/44 ; A61K31/444 ; A61P25/24 ; A61P25/16 ; A61P1/00
摘要:
The present invention relates to ethynyl derivatives of formula (I) or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. It has now surprisingly been found that the compounds of general formula (I) are metabotropic glutamate receptor antagonists (negative allosteric modulators) for use in the treatment of anxiety and pain, depression, Fragile-X syndrom, autism spectrum disorders, Parkinson's disease, and gastroesophageal reflux disease (GERD).
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