发明公开
EP2914290A1 LIQUID FORMULATION COMPRISING GM-CSF NEUTRALIZING COMPOUND
审中-公开
FLUSSIGFORMULIERUNG MIT EINER GM-CSF-NEUTRALISIERENDEN VERBINDUNG
- 专利标题: LIQUID FORMULATION COMPRISING GM-CSF NEUTRALIZING COMPOUND
- 专利标题(中): FLUSSIGFORMULIERUNG MIT EINER GM-CSF-NEUTRALISIERENDEN VERBINDUNG
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申请号: EP13798590.9申请日: 2013-10-31
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公开(公告)号: EP2914290A1公开(公告)日: 2015-09-09
- 发明人: URBIG, Thomas , BOEHM, Thomas , STEINHILBER, Wolfram , MOLHOJ, Michael
- 申请人: Amgen Research (Munich) GmbH , Takeda GmbH
- 申请人地址: Staffelseestrasse 2 81477 München DE
- 专利权人: Amgen Research (Munich) GmbH,Takeda GmbH
- 当前专利权人: Amgen Research (Munich) GmbH,Takeda GmbH
- 当前专利权人地址: Staffelseestrasse 2 81477 München DE
- 代理机构: Schiweck, Weinzierl & Koch
- 优先权: US201261720892P 20121031; EP12199191 20121221
- 国际公布: WO2014068026 20140508
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/24
摘要:
The present invention relates to aqueous formulations comprising a compound neutralizing GM-CSF in concentrations of at least about 20 mg/ml, a tonicity modifier and a buffer, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing GM-CSF in view of long-term storage. In a preferred aspect, the formulation is for use in therapy, preferably for use in the treatment of inflammatory and autoimmune disorders, preferably including allergic and psoriatic disorders, as well as arthritic and asthmatic disorders. Furthermore, a kit comprising the formulation of the invention is provided.
公开/授权文献
- EP2914290B1 LIQUID FORMULATION COMPRISING GM-CSF NEUTRALIZING COMPOUND 公开/授权日:2020-04-01
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