- 专利标题: SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF
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申请号: EP13854140.4申请日: 2013-11-07
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公开(公告)号: EP2917188B1公开(公告)日: 2018-08-01
- 发明人: BAEK, Myoung Ki , PEGAN, Augustin
- 申请人: SK Biopharmaceuticals Co., LTD
- 申请人地址: 99 Seorin-dong Jongro-gu Seoul 110-110 South Korea KR
- 专利权人: SK Biopharmaceuticals Co., LTD
- 当前专利权人: SK Biopharmaceuticals Co., LTD
- 当前专利权人地址: 99 Seorin-dong Jongro-gu Seoul 110-110 South Korea KR
- 代理机构: Nederlandsch Octrooibureau
- 优先权: KR20120125516 20121107
- 国际公布: WO2014073889 20140515
- 主分类号: A61K9/20
- IPC分类号: A61K9/20 ; A61K9/14 ; A61K9/10 ; A61K47/32 ; A61K31/42
摘要:
The present invention relates to a solid dispersion characterized in that it comprises carbamic acid 3-(4-benzyloxy-phenyl)-isoxazol-5-ylmethyl ester as an active ingredient and a water-soluble polymer having a glass transition temperature lower than the melting point of the active ingredient as a carrier, and it is prepared via melt extrusion. The solid dispersion of the present invention remarkably increases the solubility and dissolution rate of the active ingredient which is an insoluble drug to efficiently improve the bioavailability when it is orally administered.
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