发明公开
- 专利标题： PYRROLOPYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
- 专利标题（中）： 吡咯并嘧啶化合物作为激酶抑制剂
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申请号： EP13854424.2申请日： 2013-11-14
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公开(公告)号： EP2920180A1公开(公告)日： 2015-09-23
- 发明人: CHEN, Wei , LOURY, David, J. , WANG, Longcheng
- 申请人： Pharmacyclics, Inc.
- 申请人地址： 995 East Arques Avenue Sunnyvale, CA 94085 US
- 专利权人： Pharmacyclics, Inc.
- 当前专利权人： Pharmacyclics, Inc.
- 当前专利权人地址： 995 East Arques Avenue Sunnyvale, CA 94085 US
- 代理机构： Williams, Richard Andrew Norman
- 优先权： US201261727031P 20121115
- 国际公布： WO2014078578 20140522
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/519 ; A61P37/00 ; A61P35/00 ; A61P29/00
摘要：
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition, reversible inhibitors of Btk are also described. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
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