发明公开
EP2923208A1 METHODS FOR DETERMINING THE RISK OF ACUTE GRAFT VERSUS HOST DISEASE
审中-公开
方法用于确定急性移植物抗宿主病的危险
- 专利标题： METHODS FOR DETERMINING THE RISK OF ACUTE GRAFT VERSUS HOST DISEASE
- 专利标题（中）： 方法用于确定急性移植物抗宿主病的危险
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申请号： EP13792933.7申请日： 2013-11-21
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公开(公告)号： EP2923208A1公开(公告)日： 2015-09-30
- 发明人: HERMINE, Olivier , RUBIO, Marie Thérèse , BOUILLIE, Marie , LEITE DE MORAES, Maria
- 申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Assistance Publique Hôpitaux De Paris , Université Paris Descartes , Imagine Institut des Maladies Génétiques Necker Enfants Malades
- 申请人地址： 101, rue de Tolbiac 75013 Paris FR
- 专利权人： Institut National de la Santé et de la Recherche Médicale (INSERM),Centre National de la Recherche Scientifique (CNRS),Assistance Publique Hôpitaux De Paris,Université Paris Descartes,Imagine Institut des Maladies Génétiques Necker Enfants Malades
- 当前专利权人： Institut National de la Santé et de la Recherche Médicale (INSERM),Centre National de la Recherche Scientifique (CNRS),Assistance Publique Hôpitaux De Paris,Université Paris Descartes,Imagine Institut des Maladies Génétiques Necker Enfants Malades
- 当前专利权人地址： 101, rue de Tolbiac 75013 Paris FR
- 代理机构： Regimbeau
- 优先权： EP12306445 20121121
- 国际公布： WO2014079946 20140530
- 主分类号： G01N33/68
- IPC分类号： G01N33/68 ; G01N33/50 ; G01N33/569
摘要：
The present invention relates to a method for determining whether a candidate human transplant donor is at risk of inducing acute graft versus host disease (aGVHD) in a human transplant recipient, which may in turn allow the selection of a donor exhibiting no risk for the recipient. The present invention also relates to a method for adjusting the immunosuppressive treatment administered to a human transplanted recipient following its graft transplantation after having performing the method for determining risk of the invention. The methods comprise expanding the candidate donor's iNKT cells (invariant NKT cells) and determining the presence or absence of expansion of the CD4(−) iNKT cell sub-population. In particular, CD3+CD4− TCRV[alpha]24V[beta]11 cells are determined. Kits are disclosed.
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