发明公开
- 专利标题： TUMOR SPECIFIC T-CELL RECEPTORS
- 专利标题（中）： TUMORSPEZIFISCHE T-ZELLREZEPTOREN
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申请号： EP13796113.2申请日： 2013-11-29
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公开(公告)号： EP2925349A1公开(公告)日： 2015-10-07
- 发明人: BLANKENSTEIN, Thomas , WILLIMSKY, Gerald
- 申请人： Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch;
- 申请人地址： Robert-Rössle-Strasse 10 13092 Berlin DE
- 专利权人： Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch;
- 当前专利权人： Max Delbrück Centrum für Molekulare Medizin (MDC) Berlin-Buch;
- 当前专利权人地址： Robert-Rössle-Strasse 10 13092 Berlin DE
- 代理机构： Krauss, Jan
- 优先权： GB201221628 20121130; US201261731666P 20121130
- 国际公布： WO2014083173 20140605
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K14/725 ; C07K14/47
摘要：
The present invention relates to a method for the production of novel T-cell receptors (TCR) which provide a reduced risk of adverse events in immune therapy, specifically in adoptive T cell transfer. The TCRs produced according to the method of the invention are specific for tumor cells and do not react with healthy tissue. Furthermore provided are nucleic acids encoding the TCR of the invention, vectors and host cells comprising the TCRs of the invention as well as their use is the treatment of tumorous diseases.
公开/授权文献
- EP2925349B1 TUMOR SPECIFIC T-CELL RECEPTORS 公开/授权日：2019-05-08
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