- 专利标题: FUSION PROTEINS FOR USE AS IMMUNOGENIC ENHANCERS FOR INDUCING ANTIGEN-SPECIFIC T CELL RESPONSES
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申请号: EP13860917.7申请日: 2013-12-03
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公开(公告)号: EP2928491B1公开(公告)日: 2018-11-21
- 发明人: CHOU, Wei-I , WU, Chia-Mao , WU, Jiun-Ming , CHANG, Hsiu-Kang
- 申请人: TheVax Genetics Vaccine Co., Ltd.
- 申请人地址: 5F, No. 25-2, Sec. 4 Ren-ai Road Da-an District Taipei City, Taiwan 10685 CN
- 专利权人: TheVax Genetics Vaccine Co., Ltd.
- 当前专利权人: TheVax Genetics Vaccine Co., Ltd.
- 当前专利权人地址: 5F, No. 25-2, Sec. 4 Ren-ai Road Da-an District Taipei City, Taiwan 10685 CN
- 代理机构: Gill, Siân Victoria
- 优先权: US201261733879P 20121205
- 国际公布: WO2014089036 20140612
- 主分类号: A61K39/104
- IPC分类号: A61K39/104
摘要:
A fusion protein for use as an immunogen enhancer for enhancing antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen of a pathogen, wherein the APC-binding domain or the CD91 receptor-binding domain is located at the N-terminus of the fusion protein, and the antigen of the pathogen is located at the C-terminus of the protein transduction domain. The protein transduction domain is selected from the group consisting of: (i) a fusion polypeptide, comprising a T cell sensitizing signal-transducing peptide, a linker, and a translocation peptide; (ii) a T cell-sensitizing signal-transducing peptide; and (iii) a translocation peptide of 34-112 amino acid residues in length.
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