发明公开
- 专利标题： NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS
- 专利标题（中）： NUKLEOSIDKINASEBYPASS的组合物和方法
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申请号： EP13859616.8申请日： 2013-12-02
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公开(公告)号： EP2928876A1公开(公告)日： 2015-10-14
- 发明人: BUTORA, Gabor
- 申请人： Merck Sharp & Dohme Corp.
- 申请人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, NJ 07065-0907 US
- 代理机构： Jaap, David Robert
- 优先权： US201261734049P 20121206; US201361787377P 20130315
- 国际公布： WO2014088923 20140612
- 主分类号： C07D339/08
- IPC分类号： C07D339/08
摘要：
The present invention relates to disulfide masked prodrug compounds, compositions and methods that are amenable to bioactivation by a reducing agent such as glutathione. Such disulfide based compounds, compositions, and methods can be useful, for example, in providing novel prodrugs for use as therapeutics. The compounds feature a conformationally restricted disulfide phosphotriester moiety to mask anionic charge. The compounds include a 1,2-dithigne moiety.
公开/授权文献
- EP2928876B1 NUCLEOSIDE KINASE BYPASS COMPOSITIONS AND METHODS 公开/授权日：2018-01-17
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