- 专利标题： USING MIXTURES OF E/Z ISOMERS TO OBTAIN QUANTITATIVELY SPECIFIC PRODUCTS BY COMBINED ASYMMETRIC HYDROGENATIONS
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申请号： EP13811918.5申请日： 2013-12-18
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公开(公告)号： EP2935188B1公开(公告)日： 2018-08-01
- 发明人: BONRATH, Werner , MEDLOCK, Jonathan Alan , STEMMLER, René Tobias , VERZIJL, Gerardus Karel Maria , VRIES, DE, Andreas Hendrikus Maria , NETSCHER, Thomas
- 申请人： DSM IP Assets B.V.
- 申请人地址： Het Overloon 1 6411 TE Heerlen NL
- 专利权人： DSM IP Assets B.V.
- 当前专利权人： DSM IP Assets B.V.
- 当前专利权人地址： Het Overloon 1 6411 TE Heerlen NL
- 代理机构： Dux, Roland
- 优先权： EP12197850 20121218
- 国际公布： WO2014096106 20140626
- 主分类号： C07C45/62
- IPC分类号： C07C45/62 ; C07C45/82 ; C07C49/203 ; C07C49/04 ; C07C47/02
摘要：
The present invention relates to a process of manufacturing compound having stereogenic centers from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centers. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
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