发明授权
EP2938344B1 PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
有权
哌嗪丝氨酸[1,2,4]三唑并[1,5-C]喹唑啉-5-氨基 -
- 专利标题： PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
- 专利标题（中）： 哌嗪丝氨酸[1,2,4]三唑并[1,5-C]喹唑啉-5-氨基 -
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申请号： EP13867977申请日： 2013-12-20
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公开(公告)号： EP2938344B1公开(公告)日： 2017-06-21
- 发明人: ALI AMJAD , LO MICHAEL MAN-CHU , LIM YEON-HEE , STAMFORD ANDREW , KUANG RONGZE , TEMPEST PAUL , YU YOUNONG , BERLIN MICHAEL , TING PAULINE , ZHOU GANG , YU TAO , BOYCE CHRISTOPHER , KELLY JOSEPH MICHAEL , TAGAT JAYARAM R , ZHENG JUNYING , HUANG XIANHAI , ZHOU WEI , KIM JAE-HUN , ZORN NICOLAS , XIAO DONG , GALLO GIOCONDA V , WON WALTER , WU HEPING , ANAND RAJAN , DENG QIAOLIN
- 申请人： MERCK SHARP & DOHME
- 专利权人： MERCK SHARP & DOHME
- 当前专利权人： MERCK SHARP & DOHME
- 优先权： CN2012087851 2012-12-28
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; A61P25/00 ; C07D487/04
摘要：
Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.
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