发明公开
EP2938610A2 INHIBITORS OF THE USP1/UAF1 DEUBIQUITINASE COMPLEX AND USES THEREOF
审中-公开
USP1 / UAF1 DEUBIQUITIITINASE复合物的抑制剂及其用途
- 专利标题： INHIBITORS OF THE USP1/UAF1 DEUBIQUITINASE COMPLEX AND USES THEREOF
- 专利标题（中）： USP1 / UAF1 DEUBIQUITIITINASE复合物的抑制剂及其用途
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申请号： EP13821618.9申请日： 2013-12-26
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公开(公告)号： EP2938610A2公开(公告)日： 2015-11-04
- 发明人: MALONEY, David J. , ROSENTHAL, Andrew S. , JADHAV, Ajit , DEXHEIMER, Thomas S. , SIMEONOV, Anton , ZHUANG, Zhihao , LIANG, Qin , LUCI, Diane K.
- 申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services , University Of Delaware
- 申请人地址： National Institues of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20892-7660 US
- 专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services,University Of Delaware
- 当前专利权人： The U.S.A. as represented by the Secretary, Department of Health and Human Services,University Of Delaware
- 当前专利权人地址： National Institues of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, MD 20892-7660 US
- 代理机构： Pfenning, Meinig & Partner GbR
- 优先权： US201261747052P 20121228
- 国际公布： WO2014105952 20140703
- 主分类号： C07D409/12
- IPC分类号： C07D409/12 ; C07D239/94 ; C07D473/00 ; C07D487/02 ; C07D491/048 ; A61K31/517 ; A61K31/519 ; A61K31/52 ; A61K31/53
摘要：
Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R1, R2, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.
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