发明公开
EP2945944A1 NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
有权
新的取代的吡啶并哌嗪酮衍生物作为γ分泌酶调节剂的
- 专利标题： NOVEL SUBSTITUTED PYRIDO-PIPERAZINONE DERIVATIVES AS GAMMA SECRETASE MODULATORS
- 专利标题（中）： 新的取代的吡啶并哌嗪酮衍生物作为γ分泌酶调节剂的
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申请号： EP14701007.8申请日： 2014-01-16
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公开(公告)号： EP2945944A1公开(公告)日： 2015-11-25
- 发明人: BISCHOFF, François, Paul , VELTER, Adriana, Ingrid , ROMBOUTS, Frederik, Jan, Rita , DE CLEYN, Michel, Anna, Jozef , VAN BRANDT, Sven, Franciscus, Anna , GIJSEN, Henricus, Jacobus, Maria , ZAVATTARO, Chiara , VAN DEN KEYBUS, Frans, Alfons, Maria
- 申请人： Janssen Pharmaceutica, N.V.
- 申请人地址： Turnhoutseweg 30 2340 Beerse BE
- 专利权人： Janssen Pharmaceutica, N.V.
- 当前专利权人： Janssen Pharmaceutica, N.V.
- 当前专利权人地址： Turnhoutseweg 30 2340 Beerse BE
- 代理机构： Quaghebeur, Luc
- 优先权： EP13151654 20130117
- 国际公布： WO2014111457 20140724
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/498 ; A61P25/28
摘要：
The present invention is concerned with novel substituted pyrido-piperazinone derivatives of Formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
1 , R
2 , R
3 , R
4 , R
5 , L, Z and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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