发明公开
EP2954905A1 PGC-1 -PROTEIN-FUNCTION REGULATOR, MITOCHONDRIA-FUNCTION REGULATOR, ANTI-OBESITY AGENT, AND SCREENING METHOD THEREFOR
有权
PGC1蛋白功能控制，线粒体功能调节剂，MEDIUM对抗肥胖和筛选方法THEREFOR
- 专利标题： PGC-1 -PROTEIN-FUNCTION REGULATOR, MITOCHONDRIA-FUNCTION REGULATOR, ANTI-OBESITY AGENT, AND SCREENING METHOD THEREFOR
- 专利标题（中）： PGC1蛋白功能控制，线粒体功能调节剂，MEDIUM对抗肥胖和筛选方法THEREFOR
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申请号： EP13868860.1申请日： 2013-12-26
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公开(公告)号： EP2954905A1公开(公告)日： 2015-12-16
- 发明人: NAKAJIMA, Toshihiro , FUJITA, Hidetoshi , ARATANI, Satoko , YAGISHITA, Naoko
- 申请人： Nakajima, Toshihiro
- 申请人地址： 241-6, Oba-cho Aoba-ku Yokohama-shi Kanagawa 225-0023 JP
- 专利权人： Nakajima, Toshihiro
- 当前专利权人： Nakajima, Toshihiro
- 当前专利权人地址： 241-6, Oba-cho Aoba-ku Yokohama-shi Kanagawa 225-0023 JP
- 代理机构： Peters, Sebastian Martinus
- 优先权： JP2012283766 20121226; JP2013152094 20130722
- 国际公布： WO2014104224 20140703
- 主分类号： A61K45/00
- IPC分类号： A61K45/00 ; A61P3/04 ; A61P43/00 ; C12Q1/68 ; G01N33/15 ; G01N33/50
摘要：
[Problem]
To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore.
[Solution]
The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1β - protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1β protein; and (3) the ubiquitination of the PGC-1β protein by synoviolin.
To provide a mitochondria-function regulator effective for treatment or prevention of obesity, and a screening method therefore.
[Solution]
The mitochondria-function regulator of the present invention contains, as an active ingredient, a PGC-1β - protein function regulator synoviolin. The screening method of the present invention includes a step for causing a test substance to act on an adipose tissue cell or an individual animal, and measuring or detecting one or more of the following in the adipose tissue cell: (1) expression level of synoviolin; (2) a bond between synoviolin and PGC-1β protein; and (3) the ubiquitination of the PGC-1β protein by synoviolin.
公开/授权文献
- EP2954905B1 SCREENING METHOD FOR PGC-1BETA-PROTEIN-FUNCTION REGULATOR 公开/授权日：2018-05-02
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