发明公开
- 专利标题： BICYCLO- UND SPIROCYCLISCH SUBSTITUIERTE 2,3-BENZODIAZEPINE
- 专利标题（英）： Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines
- 专利标题（中）： 双环和螺环取代的2,3-苯并二氮杂
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申请号： EP14704594.2申请日： 2014-02-17
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公开(公告)号： EP2958909A1公开(公告)日： 2015-12-30
- 发明人: SIEGEL, Stephan , BÄURLE, Stefan , CLEVE, Arwed , HAENDLER, Bernard , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , MÖNNING, Ursula , KRAUSE, Sabine , LEJEUNE, Pascale , BUSEMANN, Matthias , KUHNKE, Joachim
- 申请人： Bayer Pharma Aktiengesellschaft
- 申请人地址： Müllerstrasse 178 13353 Berlin DE
- 专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人： Bayer Pharma Aktiengesellschaft
- 当前专利权人地址： Müllerstrasse 178 13353 Berlin DE
- 代理机构： BIP Patents
- 优先权： DE102013202678 20130219
- 国际公布： WO2014128067 20140828
- 主分类号： C07D401/10
- IPC分类号： C07D401/10 ; C07D403/10 ; C07D405/10 ; A61K31/551 ; A61P35/00 ; A61P37/00 ; A61P7/00 ; A61P25/28 ; A61P31/12 ; C07D451/06 ; C07D471/10 ; C07D487/04 ; C07D487/08 ; C07D487/10 ; C07D491/048
摘要：
The invention relates to BET protein-inhibiting, in particular BRD4-inhibiting, bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), to the pharmaceutical agents containing the compounds according to the invention, and to the prophylactic and therapeutic use thereof against hyper-proliferative diseases, in particular tumor diseases. The invention further relates to the use of BET protein inhibitors in benign hyperplasia, atherosclerotic diseases, sepsis, autoimmune diseases, vascular disorders, viral infections, neurodegenerative disorders, inflammatory disorders, and male fertility control.
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