发明公开
- 专利标题： BIOTIN ALTERANT, STREPTAVIDIN MUTANT, AND USES THEREOF
- 专利标题（中）： 生物素修饰剂，Streptovidin突变体及其用途
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申请号： EP14753647.8申请日： 2014-02-18
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公开(公告)号： EP2960243A1公开(公告)日： 2015-12-30
- 发明人: SUGIYAMA, Akira , DOI, Hirofumi , KODAMA, Tatsuhiko , INOUE, Tsuyoshi , MIZOHATA, Eiichi , KAWATO, Tatsuya , MESHIZUKA, Tomohiro , KANAI, Motomu , SHIMIZU, Yohei , YAMAMOTO, Tomohiro
- 申请人： Savid Therapeutics Inc.
- 申请人地址： 2-1-11 Kachidoki Chuo-ku Tokyo 104-0054 JP
- 专利权人： Savid Therapeutics Inc.
- 当前专利权人： Savid Therapeutics Inc.
- 当前专利权人地址： 2-1-11 Kachidoki Chuo-ku Tokyo 104-0054 JP
- 代理机构： Godemeyer Blum Lenze Patentanwälte Partnerschaft mbB - werkpatent
- 优先权： JP2013031038 20130220
- 国际公布： WO2014129446 20140828
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; C07D497/04 ; C07D498/04 ; C07K14/36 ; C12N15/09 ; G01N33/53
摘要：
It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin.
公开/授权文献
- EP2960243B1 BIOTIN ALTERANT, STREPTAVIDIN MUTANT, AND USES THEREOF 公开/授权日：2019-03-27
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