Methods for driving electro-optic displays, especially bistable displays, include (a) using two-part waveforms, the first part of which is dependent only upon the initial state of the relevant pixel; (b) measuring the response of each individual pixel and storing for each pixel data indicating which of a set of standard drive schemes are to be used for that pixel; (c) for at least one transition in a drive scheme, applying multiple different waveforms to pixels on a random basis; and (d) when updating a limited area of the display, driving "extra" pixels in an edge elimination region to avoid edge effects.