发明公开
EP2964221A4 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY
有权
VERBINDUNGEN ZUR HEMMUNG DERWIEDERHOLUNGSAKTIVITÄTEINES LEUKINREICHEN KINASEENZYMS
- 专利标题： COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY
- 专利标题（中）： VERBINDUNGEN ZUR HEMMUNG DERWIEDERHOLUNGSAKTIVITÄTEINES LEUKINREICHEN KINASEENZYMS
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申请号： EP14760677申请日： 2014-02-27
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公开(公告)号： EP2964221A4公开(公告)日： 2016-08-31
- 发明人: MILLER MICHAEL , BASU KALLOL , DEMONG DUANE , SCOTT JACK , LIU HONG , DAI XING , HARRIS JOEL M , NEUSTADT BERNARD , STAMFORD ANDREW W , POIRIER MARC , MCCAULEY JOHN A , GRESHOCK THOMAS , STEVENSON HEATHER , SANDERS JOHN , KERN JONATHAN
- 申请人： MERCK SHARP & DOHME
- 专利权人： MERCK SHARP & DOHME
- 当前专利权人： MERCK SHARP & DOHME
- 优先权： US201361772009 2013-03-04
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; C07D231/56
摘要：
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
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