发明授权
- 专利标题: MORPHINAN DERIVATIVE
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申请号: EP13877360.1申请日: 2013-10-15
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公开(公告)号: EP2966074B1公开(公告)日: 2018-07-25
- 发明人: NAGASE, Hiroshi , FUJII, Hideaki , NAKATA, Eriko , WATANABE, Yoshikazu , SAITO, Daisuke , TAKAHASHI, Toshihiro
- 申请人: The Kitasato Institute , Nippon Chemiphar Co., Ltd.
- 申请人地址: 9-1, Shirokane 5-chome Minato-ku Tokyo 108-8641 JP
- 专利权人: The Kitasato Institute,Nippon Chemiphar Co., Ltd.
- 当前专利权人: The Kitasato Institute,Nippon Chemiphar Co., Ltd.
- 当前专利权人地址: 9-1, Shirokane 5-chome Minato-ku Tokyo 108-8641 JP
- 代理机构: Godemeyer Blum Lenze Patentanwälte Partnerschaft mbB - werkpatent
- 优先权: JP2013047325 20130308
- 国际公布: WO2014136305 20140912
- 主分类号: C07D471/08
- IPC分类号: C07D471/08 ; C07D471/10 ; C07D491/20 ; A61K31/439 ; A61P25/04 ; A61P25/22
摘要:
The present invention relates to a morphinan derivative represented by the following general formula (I), wherein R 1 represents hydrogen, C 1-6 alkyl, C 6-10 aryl, etc., R 2 and R 3 , which are the same or different, represent hydrogen, hydroxy, ect., R 4 and R 5 represent hydrogen, C 1-6 alkyl, etc., R 6 represents hydrogen, hydroxy, C 1 - 6 alkyl, etc., X represents O or CH 2 , Y represents C=O, C(=O)O, etc., and m and n, which are the same or different, represent an integer of 0 to 2 (m and n are not 0 at the same time), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof, as well as an analgesic, antianxiety drug, etc. containing the same as an active ingredient.
公开/授权文献
- EP2966074A1 MORPHINAN DERIVATIVE 公开/授权日:2016-01-13
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