- 专利标题： DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS
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申请号： EP14723553.5申请日： 2014-03-14
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公开(公告)号： EP2970225B1公开(公告)日： 2018-08-15
- 发明人: MCMINN, Dustin , JOHNSON, Henry , MOEBIUS, David, C.
- 申请人： Onyx Therapeutics, Inc.
- 申请人地址： One Amgen Center Drive Thousand Oaks, CA 91320 US
- 专利权人： Onyx Therapeutics, Inc.
- 当前专利权人： Onyx Therapeutics, Inc.
- 当前专利权人地址： One Amgen Center Drive Thousand Oaks, CA 91320 US
- 代理机构： Bailey, Sam Rogerson
- 优先权： US201361785608P 20130314; US201361786086P 20130314; US201361847780P 20130718; US201361856847P 20130722; US201361883798P 20130927; US201361883843P 20130927; US201461941798P 20140219
- 国际公布： WO2014152127 20140925
- 主分类号： C07D405/12
- IPC分类号： C07D405/12 ; A61K31/336 ; A61K31/404 ; C07D409/12 ; C07D303/32 ; A61P37/00
摘要：
Provided herein are dipeptide and tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of proliferative diseases including cancer and autoimmune diseases.
公开/授权文献
- EP2970225A1 DIPEPTIDE AND TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS 公开/授权日：2016-01-20
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