发明公开
- 专利标题: NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
- 专利标题(中): 新型的磷酸二酯酶抑制剂化合物10A
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申请号: EP14709693.7申请日: 2014-03-13
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公开(公告)号: EP2970258A1公开(公告)日: 2016-01-20
- 发明人: GENESTE, Hervé , OCHSE, Michael , DRESCHER, Karla , BEHL, Berthold , LAPLANCHE, Loic , DINGES, Jürgen , JAKOB, Clarissa
- 申请人: AbbVie Deutschland GmbH & Co KG , AbbVie Inc.
- 申请人地址: Max-Planck-Ring 2a 65205 Wiesbaden DE
- 专利权人: AbbVie Deutschland GmbH & Co KG,AbbVie Inc.
- 当前专利权人: AbbVie Deutschland GmbH & Co KG,AbbVie Inc.
- 当前专利权人地址: Max-Planck-Ring 2a 65205 Wiesbaden DE
- 代理机构: Reitstötter Kinzebach
- 优先权: US201361781648P 20130314
- 国际公布: WO2014140184 20140918
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; C07D519/00 ; A61P25/00 ; A61K31/437 ; A61K31/4709 ; A61K31/5377 ; A61K31/541 ; A61K31/444 ; A61K31/506
摘要:
The present invention relates to compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof: In formula I the variables Het, A, X, Y, Z, R1, R2, R3, R4, R5 and Q are as defined in the claims. The compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A. Thus, the invention also relates to the use of the compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.
公开/授权文献
- EP2970258B1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A 公开/授权日:2018-04-18
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