发明公开
- 专利标题： MACROCYCLIC LRRK2 KINASE INHIBITORS
- 专利标题（中）： MAKROCYCLISCHE LRRK2-KINASEHEMMER
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申请号： EP14709962.6申请日： 2014-03-14
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公开(公告)号： EP2970333A1公开(公告)日： 2016-01-20
- 发明人: HOFLACK, Jan , BLOM, Petra , LAVERGNE, Olivier
- 申请人： IPSEN PHARMA S.A.S. , Oncodesign S.A.
- 申请人地址： 65 quai Georges Gorse 92100 Boulogne Billancourt FR
- 专利权人： IPSEN PHARMA S.A.S.,Oncodesign S.A.
- 当前专利权人： IPSEN PHARMA S.A.S.,Oncodesign S.A.
- 当前专利权人地址： 65 quai Georges Gorse 92100 Boulogne Billancourt FR
- 代理机构： Bounaga, Sakina
- 优先权： EP13305311 20130315; EP13305314 20130315
- 国际公布： WO2014140235 20140918
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; A61K31/437 ; A61K31/504 ; A61P25/16
摘要：
The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 kinase, for use in the diagnosis, prevention and/or treatment of LRRK2 -kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent. Finally, the present invention also relates to new macrocyclic compounds.
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