发明公开
EP2970426A2 TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY
审中-公开
ANZIELUNG ZYTOTOXISCHER ZELLEN MITCHIMÄRENREZEPTORENFÜREINE ADOPTIVE IMMUNTHERAPIE
- 专利标题： TARGETING CYTOTOXIC CELLS WITH CHIMERIC RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY
- 专利标题（中）： ANZIELUNG ZYTOTOXISCHER ZELLEN MITCHIMÄRENREZEPTORENFÜREINE ADOPTIVE IMMUNTHERAPIE
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申请号： EP14722891.0申请日： 2014-03-15
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公开(公告)号： EP2970426A2公开(公告)日： 2016-01-20
- 发明人: Milone, Michael C. , Wang, Enxiu
- 申请人： Milone, Michael C. , Wang, Enxiu
- 申请人地址： 314 Surrey Road Cherry Hill, NJ 08002 US
- 专利权人： Milone, Michael C.,Wang, Enxiu
- 当前专利权人： Milone, Michael C.,Wang, Enxiu
- 当前专利权人地址： 314 Surrey Road Cherry Hill, NJ 08002 US
- 代理机构： Wilding, James Roger
- 优先权： US201361793443P 20130315
- 国际公布： WO2014145252 20140918
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C07K19/00
摘要：
The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “KIR-CAR” which is a CAR design comprising a component of a receptor naturally found on natural killer (NK) cells. In one embodiment, the NK receptor includes but is not limited to a naturally occurring activating and inhibitory receptor of NK cells known as a killer cell immunoglobulin-like receptor (KIR).
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