- 专利标题: LIQUID AQUEOUS COMPOSITION
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申请号: EP14764228.4申请日: 2014-03-11
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公开(公告)号: EP2974734B1公开(公告)日: 2018-10-10
- 发明人: NAKATANI, Tomomi , SAITO, Koichi
- 申请人: Sumitomo Dainippon Pharma Co., Ltd.
- 申请人地址: 6-8, Dosho-machi 2-chome Chuo-ku Osaka-shi Osaka 541-8524 JP
- 专利权人: Sumitomo Dainippon Pharma Co., Ltd.
- 当前专利权人: Sumitomo Dainippon Pharma Co., Ltd.
- 当前专利权人地址: 6-8, Dosho-machi 2-chome Chuo-ku Osaka-shi Osaka 541-8524 JP
- 代理机构: J A Kemp
- 优先权: US201361777423P 20130312
- 国际公布: WO2014142102 20140918
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; A61P35/00 ; C07K7/06 ; C07K14/82 ; A61K47/12 ; A61K39/00
摘要:
Provided is an aqueous liquid composition comprising a WT1 protein-derived cancer antigen peptide, wherein the peptide is stabilized. An aqueous liquid composition comprising a peptide and an excipient, and having a pH of 3 - 6: wherein the peptide is selected from the group consisting of the following (A) and (B), (A) a peptide consisting of the amino acid sequence shown by Arg-Met-Phe-Pro-Asn-Ala-Pro-Tyr-Leu (SEQ ID NO: 1), and (B) a peptide consisting of the amino acid sequence shown by SEQ ID NO: 1, wherein 1 to 3 amino acids are deleted, substituted and/or added, and having a cytotoxic T cell-inducing ability; and the excipient contains one or more kinds selected from the group consisting of the following (C), (D) and (E), (C) one or more kinds of alpha hydroxy acids selected from the group consisting of glycolic acid, lactic acid, malic acid, tartaric acid, citric acid and pharmacologically acceptable salts thereof, (D) one or more kinds of dicarboxylic acids selected from the group consisting of malonic acid, succinic acid, glutaric acid, maleic acid and pharmacologically acceptable salts thereof, and (E) methionine.
公开/授权文献
- EP2974734A1 LIQUID AQUEOUS COMPOSITION 公开/授权日:2016-01-20
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