A bottle blowing machine is provided in the invention. The bottle blowing machine comprises a machine frame, a mould opening and closing assembly, an elevating assembly, a bottom mould locking assembly and a driving assembly. The mould opening and closing assembly comprises a bottom mould, a fixed mould plate and a moving mould plate. The elevating assembly comprises a protrusion, an elevating rod and a sliding block. A guiding groove is opened on the protrusion, and the sliding block is slidably disposed in the guiding groove. The bottom mould is fixed on the upper end of the elevating rod. The bottom mould locking assembly comprises a rotation member, a swing member and a sliding block slidably disposed on the machine frame. The driving assembly comprises a rotation shaft and a power source for driving the rotation of the rotation shaft. The moving mould plate, the protrusion and the rotation member are simultaneously fixedly connected with the rotation shaft. When the rotation shaft rotates, the fixed mould plate and the moving mould plate close the mould, the elevating rod drives the bottom mould to rise, and the sliding block slides into between the machine frame and a bottom mould. In the bottle blowing machine of the invention, three assemblies are simultaneously driven only by one rotation shaft to move, and the steps of mould closing, elevating and locking are operated simultaneously. Thus, the bottle blowing machine of the invention is simple in structure and convenient in operation, thereby improving the efficiency of the process of bottle blowing.