发明公开
- 专利标题： N-terminally truncated interleukin-38
- 专利标题（中）： N-末端verkürztes白细胞介素-38
-
申请号： EP14178478.5申请日： 2014-07-25
-
公开(公告)号： EP2977384A1公开(公告)日： 2016-01-27
- 发明人: Weigert, Andreas , Mora, Javier , Brüne, Bernhard , Dillmann, Christina , Parnham, Michael John , Geisslinger, Gerd
- 申请人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. , Johann Wolfgang Goethe-Universität, Frankfurt am Main
- 申请人地址： Hansastrasse 27 c 80686 München DE
- 专利权人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V.,Johann Wolfgang Goethe-Universität, Frankfurt am Main
- 当前专利权人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V.,Johann Wolfgang Goethe-Universität, Frankfurt am Main
- 当前专利权人地址： Hansastrasse 27 c 80686 München DE
- 代理机构： Krauss, Jan
- 主分类号： C07K14/54
- IPC分类号： C07K14/54
摘要：
The present invention pertains to an N-terminally truncated interleukin (IL)-38 protein, or functional variants thereof, as well as to nucleic acids and vectors encoding the truncated IL-38 peptide and recombinant cells comprising these nucleic acids or vectors. The invention shows that IL-38 is N-terminally processed and that the truncated version of the cytokine acts as an antagonist of immune activation in macrophages. This indicates a use of the truncated cytokine in the treatment and prevention of autoimmune disorders. The invention further provides pharmaceutical compositions comprising the truncated IL-38 protein, and method for screening modulators of the function of truncated IL-38.
信息查询
