发明公开
EP2981611A4 ANTIBIOTIC PROTOCELLS AND RELATED PHARMACEUTICAL FORMULATIONS AND METHODS OF TREATMENT
审中-公开
抗生素-PROTOZELLEN SOWIE PHARMAZEUTISCHE FORMULIERUNGEN UND BEHANDLUNGSVERFAHREN DAMIT
- 专利标题： ANTIBIOTIC PROTOCELLS AND RELATED PHARMACEUTICAL FORMULATIONS AND METHODS OF TREATMENT
- 专利标题（中）： 抗生素-PROTOZELLEN SOWIE PHARMAZEUTISCHE FORMULIERUNGEN UND BEHANDLUNGSVERFAHREN DAMIT
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申请号： EP14779421申请日： 2014-04-02
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公开(公告)号： EP2981611A4公开(公告)日： 2016-11-16
- 发明人: ASHLEY CARLEE ERIN , CARNES ERIC C , WU TERRY , FELTON LINDA A , SASAKI DARRYL Y
- 申请人： STC UNM , SANDIA CORP
- 专利权人： STC UNM,SANDIA CORP
- 当前专利权人： STC UNM,SANDIA CORP
- 优先权： US201361807679 2013-04-02
- 主分类号： C12N11/14
- IPC分类号： C12N11/14 ; A61K9/127 ; A61K9/51 ; A61K35/66 ; A61K47/48 ; A61P31/00 ; C12N11/08
摘要：
The invention provides novel antibiotic protocells comprising mesoporous nanoparticles encapsulated within a lipid bi- or multilayer. The nanoparticles have pore sizes and surface chemistries that enable facile adsorption and intracellular presentation of antibiotics which are effective in the treatment of a wide variety of bacterial infections, including F. tularensis, B. pseudomallei and P. aeruginosa-related infections. Related pharmaceutical compositions and methods of treatment are also provided.
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